To observe the changes of serum proteins according to the process of Babesia gibsoni(B gibsoni) infection, the babesia protozoa(10^8/㎏) were inoculated into the cephalic vein of healthy dogs. The serum proteins of experimentally infected dogs were separated by using cellulose acetate electrophoresis.
The results obtained were as follows;
1. Cellulose acetate electrophoresis was fractionated to total 6 of bands such as, albumin, α₁,α₂,β₁,β₂and γ-globulin.
2. The concentration of total protein was shown a decreasing tendency after B gibsoni infection. Albumin and A/G ratio were lowered through all periods of the infection, but they were not significant changes.
3. The level of α₁,-globulin was significantly(p<0.05) increased in early stage of the infection.
4. The levels of α₂ and total α-globulin were shown highly significant decreases (p<0.01) through all periods of the infection.
5. The levels of β₁, and total β-globulin had highly significant changes (p<0.01) that was increased in early stage of infection and decreased later.
6. The level of γ-globulin was seen to he constantly increased through all periods of infection. It was a highly significant change (p<0.01).
7. Plasma protein: fibrinogen (PP:F) ratio was shown a temporally significant increase (p<0.05) following the decrease in early infection.
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